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Journal Article

Transitions for regulating early transcription.

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Cramer,  P.
Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society;

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Michel, M., & Cramer, P. (2013). Transitions for regulating early transcription. Cell, 153(5), 943-944. doi:10.1016/j.cell.2013.04.050.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0015-379F-0
Abstract
Gene expression is largely regulated during the initiation of RNA polymerase II (PolII) transcription. In this issue, Kouzine et al. show that control of DNA melting is one of the critical rate-limiting steps for productive mRNA elongation. We discuss these findings in the context of other key energetic transitions.