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Struggling to let go: A non‐coding RNA directs its own extension and destruction

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Cramer,  P.
Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society;

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Citation

Bernecky, C., & Cramer, P. (2013). Struggling to let go: A non‐coding RNA directs its own extension and destruction. EMBO Journal, 32(6), 771-772. doi:10.1038/emboj.2013.36.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0015-3C73-E
Abstract
In addition to its role in DNA-dependent transcription, RNA polymerase II (Pol II) possesses RNA-dependent RNA polymerase (RdRP) activity (Lehmann et al, 2007). In a study published in this issue of The EMBO Journal, Wagner et al (2013) report the first native cellular function of the RdRP activity of Pol II. The authors find that a mammalian non-coding RNA (ncRNA) can serve as a template for its own extension by Pol II, resulting in its destabilization and a decrease in its potency to repress Pol II.