Nuclear import of HIV‐1 intracellular reverse transcription complexes is 
mediated by importin 7.

Fassati, A.; Görlich, D.; Harrison, I.; Zaytseva, I.; Mingot, J. M.

doi:10.1093/emboj/cdg357

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Journal Article

Nuclear import of HIV‐1 intracellular reverse transcription complexes is mediated by importin 7.

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Görlich, D.
Department of Cellular Logistics, MPI for biophysical chemistry, Max Planck Society;

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1932970_Suppl_1.pdf
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Citation

Fassati, A., Görlich, D., Harrison, I., Zaytseva, I., & Mingot, J. M. (2003). Nuclear import of HIV‐1 intracellular reverse transcription complexes is mediated by importin 7. The EMBO Journal, 22(14), 3675-3685. doi:10.1093/emboj/cdg357.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0015-3DD0-1

Abstract

Human immunodeficiency virus type 1 (HIV‐1), like other lentiviruses, can infect non‐dividing cells. This property depends on the active nuclear import of its intracellular reverse transcription complex (RTC). We have studied nuclear import of purified HIV‐1 RTCs in primary macrophages and found that importin 7, an import receptor for ribosomal proteins and histone H1, is involved in the process. Nuclear import of RTCs requires, in addition, energy and the com ponents of the Ran system. Depletion of importin 7 from cultured cells by small interfering RNA inhibits HIV‐1 infection. These results provide a new insight into the molecular mechanism for HIV‐1 nuclear import and reveal potential targets for therapeutic intervention.