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Journal Article

A movie of RNA polymerase II transcription

MPS-Authors
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Cramer,  P.
Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society;

Fulltext (public)

1933063.pdf
(Publisher version), 752KB

Supplementary Material (public)

1933063-Suppl-1.mov
(Supplementary material), 4MB

Citation

Cheung, A. C. M., & Cramer, P. (2012). A movie of RNA polymerase II transcription. Cell, 149(7), 1431-1437. doi:10.1016/j.cell.2012.06.006.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0015-3E91-7
Abstract
We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition. The movie reveals open questions about the mechanism of transcription and provides a useful teaching tool.