Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by 
restricting their tangential migration

Dimidschstein, Jordane; Passante, Lara; Dufour, Audrey; van den Ameele, Jelle; Tiberi, Luca; Hrechdakian, Tatyana; Adams, Ralf; Klein, Rüdiger; Lie, Dieter Chichung; Jossin, Yves; Vanderhaeghen, Pierre

doi:10.1016/j.neuron.2013.07.015

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Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration

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Klein, Rüdiger
Department: Molecules-Signaling-Development / Klein, MPI of Neurobiology, Max Planck Society;

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Citation

Dimidschstein, J., Passante, L., Dufour, A., van den Ameele, J., Tiberi, L., Hrechdakian, T., et al. (2013). Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration. Neuron, 79(6), 1123-1135. doi:10.1016/j.neuron.2013.07.015.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0015-7918-6

Abstract

Neurons of the cerebral cortex are organized in layers
and columns. Unlike laminar patterning, the mechanisms
underlying columnar organization remain
largely unexplored. Here, we show that ephrin-B1
plays a key role in this process through the control
of nonradial steps of migration of pyramidal neurons.
In vivo gain of function of ephrin-B1 resulted in a
reduction of tangential motility of pyramidal neurons,
leading to abnormal neuronal clustering. Conversely,
following genetic disruption of ephrin-B1, cortical
neurons displayed a wider lateral dispersion, resulting
in enlarged ontogenic columns. Dynamic analyses
revealed that ephrin-B1 controls the lateral spread of
pyramidal neurons by limiting neurite extension and
tangential migration during the multipolar phase.
Furthermore, we identified P-Rex1, a guanine-exchange
factor for Rac3, as a downstream ephrin-B1
effector required to control migration during the multipolar
phase. Our results demonstrate that ephrin-B1
inhibits nonradial migration of pyramidal neurons,
thereby controlling the pattern of cortical columns.