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Journal Article

DNA photodamage recognition by RNA polymerase II.

MPS-Authors
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Cramer,  P.
Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society;

Fulltext (public)

1937330.pdf
(Publisher version), 666KB

Supplementary Material (public)
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Citation

Brückner, F., & Cramer, P. (2007). DNA photodamage recognition by RNA polymerase II. FEBS Letters, 581(15), 2757-2760. doi:10.1016/j.febslet.2007.05.014.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0015-80E8-E
Abstract
During gene transcription, RNA polymerase (Pol) II encounters obstacles, including lesions in the DNA template. Here, we review a recent structure–function analysis of Pol II transcribing DNA with a bulky photo-lesion in the template strand. The study provided the molecular basis for recognition of a damaged DNA by Pol II, which is the first step in transcription-coupled DNA repair (TCR). The results have general implications for damage recognition and the TCR mechanism.