Uniform transitions of the general RNA polymerase II transcription complex.

Mayer, A.; Lidschreiber, M.; Siebert, M.; Leike, K.; Söding, J.; Cramer, P.

doi:10.1038/nsmb.1903

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Uniform transitions of the general RNA polymerase II transcription complex.

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Söding, J.
Research Group of Computational Biology, MPI for Biophysical Chemistry, Max Planck Society;

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Cramer, P.
Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society;

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Citation

Mayer, A., Lidschreiber, M., Siebert, M., Leike, K., Söding, J., & Cramer, P. (2010). Uniform transitions of the general RNA polymerase II transcription complex. Nature Structural and Molecular Biology, 17(10), 1272-1278. doi:10.1038/nsmb.1903.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0015-8216-5

Abstract

The genome-wide occupancy profiles for yeast RNA polymerase II in different phosphorylated forms, as well as transcription factors, are presented. The resulting analysis captures a 5' transition in which initiation factors are replaced by a general set of elongation factors that form a productive complex, which disassembles in two steps at the 3' end of the gene.