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Journal Article

Towards molecular systems biology of gene transcription and regulation

MPS-Authors
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Cramer,  P.
Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society;

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http://www.degruyter.com/view/j/bchm.2010.391.issue-7/bc.2010.094/bc.2010.094.xml
(Publisher version)

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1940392.pdf
(Publisher version), 282KB

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Citation

Cramer, P. (2010). Towards molecular systems biology of gene transcription and regulation. Biological Chemistry, 391(7), 731-735. doi:10.1515/BC.2010.094.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0015-8376-7
Abstract
Ten years after the determination of the RNA polymerase II structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural biology, biochemistry, functional genomics, and computational methods. In this article, the efforts of our laboratory to move from an integrated structural biology of gene transcription towards molecular systems biology of gene regulation are reviewed.