The VASP tetramerization domain is a right-handed coiled coil based on a 
15-residue repeat.

Kühnel, K.; Jarchau, T.; Wolf, E.; Schlichting, I.; Walter, U.; Wittinghofer, A.; Strelkov, S. V.

doi:10.1073/pnas.0403069101

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The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat.

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Kühnel, K.
Research Group of Autophagy, MPI for Biophysical Chemistry, Max Planck Society;

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Citation

Kühnel, K., Jarchau, T., Wolf, E., Schlichting, I., Walter, U., Wittinghofer, A., et al. (2004). The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. Proceedings of the National Academy of Sciences of the United States of America, 101(49), 17027-17032. doi:10.1073/pnas.0403069101.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0015-8B1E-B

Abstract

The vasodilator-stimulated phosphoprotein (VASP) is a key regulator of actin dynamics. We have determined the 1.3-Å resolution crystal structure of the 45-residue-long tetramerization domain (TD) from human VASP. This domain forms a right-handed α-helical coiled-coil structure with a similar degree of supercoiling as found in the widespread left-handed coiled coils with heptad repeats. The basis for the right-handed geometry of VASP TD is a 15-residue repeat in its amino acid sequence, which reveals a characteristic pattern of hydrophobic residues. Hydrophobic interactions and a network of salt bridges render VASP TD highly thermostable with a melting point of 120°C.