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Structure-function relationships of ErbB RTKs in the plasma membrane of living cells

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Arndt-Jovin,  D. J.
Emeritus Group Laboratory of Cellular Dynamics, MPI for Biophysical Chemistry, Max Planck Society;

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Jovin,  T. M.
Emeritus Group Laboratory of Cellular Dynamics, MPI for Biophysical Chemistry, Max Planck Society;

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Citation

Arndt-Jovin, D. J., Gralle Botelho, M., & Jovin, T. M. (2014). Structure-function relationships of ErbB RTKs in the plasma membrane of living cells. In J. Schlessinger, & M. A. Lemmon (Eds.), Signaling by Receptor Tyrosine Kinases. A subject collection from Cold Spring Harbor Perspectives in Biology (4, pp. 193-206). Cold Spring Harbor, N.Y.: Cold Spring Harbor Lab. Pr.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0018-6FC0-4
Abstract
We review the states of the ErbB family of receptor tyrosine kinases (RTKs), primarily the EGF receptor (EGFR, ErbB1, HER1) and the orphan receptor ErbB2 as they exist in living mammalian cells, focusing on four main aspects: (1) aggregation state and distribution in the plasma membrane; (2) conformational features of the receptors situated in the plasma membrane, compared to the crystallographic structures of the isolated extracellular domains; (3) coupling of receptor disposition on filopodia with the transduction of signaling ligand gradients; and (4) ligand-independent receptor activation by application of a magnetic field.