Dopamine and glutamate receptor genes interactively influence episodic memory 
in old age

Papenberg, G.; Li, S. C.; Nagel, I. E.; Nietfeld, W.; Schjeide, B. M.; Schröder, J.; Bertram, L.; Heekeren, Hauke R.; Lindenberger, U.; Bäckman, L.

doi:ARTN 1213.e3DOI 10.1016/j.neurobiolaging.2013.11.014

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Dopamine and glutamate receptor genes interactively influence episodic memory in old age

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Nietfeld, W.
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Schjeide, B. M.
Neuropsychiatric Genetics (Lars Bertram), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

Schröder, J.
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Bertram, L.
Neuropsychiatric Genetics (Lars Bertram), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Papenberg, G., Li, S. C., Nagel, I. E., Nietfeld, W., Schjeide, B. M., Schröder, J., et al. (2014). Dopamine and glutamate receptor genes interactively influence episodic memory in old age. Neurobiology of Aging, 35(5), 1213.e3-1213.e8. doi:ARTN 1213.e3DOI 10.1016/j.neurobiolaging.2013.11.014.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0018-F9BB-C

Abstract

Both the dopaminergic and glutamatergic systems modulate episodic memory consolidation. Evidence from animal studies suggests that these two neurotransmitters may interact in influencing memory performance. Given that individual differences in episodic memory are heritable, we investigated whether variations of the dopamine D2 receptor gene (rs6277, C957T) and the N-methyl-D-aspartate 3A (NR3A) gene, coding for the N-methyl-D-aspartate 3A subunit of the glutamate N-methyl-D-aspartate receptor (rs10989591, Val362Met), interactively modulate episodic memory in large samples of younger (20-31 years; n = 670) and older (59-71 years; n = 832) adults. We found a reliable gene-gene interaction, which was observed in older adults only: older individuals carrying genotypes associated with greater D2 and N-methyl-D-aspartate receptor efficacy showed better episodic performance. These results are in line with findings showing magnification of genetic effects on memory in old age, presumably as a consequence of reduced brain resources. Our findings underscore the need for investigating interactive effects of multiple genes to understand individual difference in episodic memory. (C) 2014 Elsevier Inc. All rights reserved.