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Designer cells for stereocomplementary de novo enzymatic cascade reactions based on laboratory evolution

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Agudo Torres,  Rubén
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Reetz,  Manfred T.
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Univ Marburg, Fachbereich Chemie;

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Citation

Agudo Torres, R., & Reetz, M. T. (2013). Designer cells for stereocomplementary de novo enzymatic cascade reactions based on laboratory evolution. Chemical Communications, 49(93), 10914-10916. doi:10.1039/c3cc46229c.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0018-D5E6-8
Abstract
Designer cells for a synthetic cascade reaction harnessing selective redox reactions were devised, featuring two successive regioselective P450-catalyzed CH-activating oxidations of 1-cyclohexene carboxylic acid methyl ester followed by stereoselective olefin-reduction catalysed by (R)- or (S)-selective mutants of an enoate reductase.