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Enzyme Promiscuity: Using a P450 Enzyme as a Carbene Transfer Catalyst

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Roiban,  Georghe-Doru
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Reetz,  Manfred T.
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Philipps-Universität Marburg, Fachbereich Chemie;

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Citation

Roiban, G.-D., & Reetz, M. T. (2013). Enzyme Promiscuity: Using a P450 Enzyme as a Carbene Transfer Catalyst. Angewandte Chemie International Edition: a journal of the Gesellschaft Deutscher Chemiker, 52(21), 5439-5440. doi:10.1002/anie.201301083.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0018-D5D8-8
Abstract
How about this for a change: The promiscuous enzyme cytochrome P450-BM3 catalyzes the cyclopropanation of olefins, sometimes with high stereoselectivity (see scheme). The highlighted paper demonstrates that it is possible to design unusual enzyme promiscuity.