The Importance of Additive and Non-Additive Mutational Effects in Protein 
Engineering

Reetz, Manfred T.

doi:10.1002/anie.201207842

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The Importance of Additive and Non-Additive Mutational Effects in Protein Engineering

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Reetz, Manfred T.
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Univ Marburg;

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Reetz, M. T. (2013). The Importance of Additive and Non-Additive Mutational Effects in Protein Engineering. Angewandte Chemie International Edition: a journal of the Gesellschaft Deutscher Chemiker, 52(10), 2658-2666. doi:10.1002/anie.201207842.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0018-D5CA-8

Abstract

Additive or non-additive, that is the question: The increasing awareness of non-additive cooperative mutational effects in protein engineering is currently providing new theoretical and practical insights. In particular, the directed evolution of stereoselective enzymes as catalysts in organic chemistry and biotechnology profits from this intriguing development.