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Journal Article

Mutual Synchronization of Molecular Turnover Cycles in Allosteric Enzymes

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Stange,  Pedro
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Hess,  Benno
Emeritus Group Prof. Dr. B. Hess, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Stange, P., Mikhailov, A. S., & Hess, B. (1998). Mutual Synchronization of Molecular Turnover Cycles in Allosteric Enzymes. The Journal of Physical Chemistry B, 102(32), 6273-6289. doi:10.1021/jp9813185.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-A52E-F
Abstract
The diffusive transport and mixing times of regulatory molecules in micrometer and submicrometer reaction volumes can be shorter than characteristic times of conformational transformations in single enzyme molecules. Under these conditions, mutual synchronization of individual molecular turnover cycles takes place when strong allosteric activation by the reaction products is present. Using simple automaton models to describe the cycles of single molecules, we analyze properties of the synchronization transition and the role of statistical fluctuations in the synchronization phenomena.