The solution structure of the first KH domain of FMR1, the protein responsible 
for the fragile X syndrome

Musco, Giovanna; Kharrat, A.; Stier, Gunter; Fraternali, F.; Gibson, Toby J.; Nilges, Michael; Pastore, Annalisa

doi:10.1038/nsb0997-712

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The solution structure of the first KH domain of FMR1, the protein responsible for the fragile X syndrome

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Stier, Gunter
Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Musco, G., Kharrat, A., Stier, G., Fraternali, F., Gibson, T. J., Nilges, M., et al. (1997). The solution structure of the first KH domain of FMR1, the protein responsible for the fragile X syndrome. Nature Structural and Molecular Biology, 4(9), 712-716. doi:10.1038/nsb0997-712.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-A592-9

Abstract

The structure and dynamics of the first KH domain of FMR1 - the protein responsible for fragile X syndrome - reveal that an exposed loop is highly flexible despite containing a GxxG motif that is well conserved throughout the KH family. We suggest that this region provides a putative binding surface for RNA recognition.