Domain interaction between NMDA receptor subunits and the postsynaptic density 
protein PSD-95

Kornau, Hans Christian; Schenker, Leslie T.; Kennedy, Mary B.; Seeburg, Peter H.

doi:10.1126/science.7569905

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Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

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Kornau, Hans Christian
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Seeburg, Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Kornau, H. C., Schenker, L. T., Kennedy, M. B., & Seeburg, P. H. (1995). Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science, 269(5231), 1737-1740. doi:10.1126/science.7569905.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-A791-C

Abstract

The N-methyl-D-aspartate (NMDA) receptor subserves synaptic glutamate-induced transmission and plasticity in central neurons. The yeast two-hybrid system was used to show that the cytoplasmic tails of NMDA receptor subunits interact with a prominent postsynaptic density protein PSD-95. The second PDZ domain in PSD-95 binds to the seven-amino acid, COOH-terminal domain containing the terminal tSXV motif (where S is serine, X is any amino acid, and V is valine) common to NR2 subunits and certain NR1 splice forms. Transcripts encoding PSD-95 are expressed in a pattern similar to that of NMDA receptors, and the NR2B subunit co-localizes with PSD-95 in cultured rat hippocampal neurons. The interaction of these proteins may affect the plasticity of excitatory synapses.