Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the 
CNS

Jonas, Peter; Spruston, Nelson

doi:10.1016/0959-4388(94)90098-1

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Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS

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Jonas, Peter
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Spruston, Nelson
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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https://www.sciencedirect.com/science/article/pii/0959438894900981/pdf?md5=80810b87c99f8f4919075ccd4ea36b31&pid=1-s2.0-0959438894900981-main.pdf
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Citation

Jonas, P., & Spruston, N. (1994). Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS. Current Opinion in Neurobiology, 4(3), 366-372. doi:10.1016/0959-4388(94)90098-1.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-A910-D

Abstract

Excitatory postsynaptic currents in neurones of the central nervous system have a dual-component time course that results from the co-activation of AMPA/kainate-type and NMDA-type glutamate receptors. New approaches in electrophysiology and molecular biology have provided a better understanding of the factors that determine the kinetics of excitatory postsynaptic currents. Recent studies suggest that the time course of neurotransmitter concentration in the synaptic cleft, the gating properties of the native channels, and the glutamate receptor subunit composition all appear to be important factors.