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Hypothesis: Intermediate filament and related proteins: Potential activators of nucleosomes during transcription initiation and elongation?

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Traub,  Peter
Max Planck Institute for Medical Research, Max Planck Society;

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Shoeman,  Robert L.
Coherent diffractive imaging, Max Planck Institute for Medical Research, Max Planck Society;
Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society;
Analytical Protein Biochemistry, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Traub, P., & Shoeman, R. L. (1994). Hypothesis: Intermediate filament and related proteins: Potential activators of nucleosomes during transcription initiation and elongation? Bioessays, 16(5), 349-355. doi:10.1002/bies.950160510.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0019-A915-3
Abstract
Intermediate filament (IF) protein tetramers contain two DNA- and core-histone-binding motifs in rotational symmetry in one and the same structural entity. We propose that IF protein oligomers might displace histone octamers from nucleosomes in the process of transcription initiation and elongation, to deposit them transiently on their α-helical coiled-coil domains. We further propose that structurally related proteins of the karyoskeleton, constructed from an α-helical domain capable of coiled-coil formation and a basic DNA-binding region adjacent to it, may be similarly involved in nucleosome activation. These proteins would function as auxiliary factors that disrupt nucleosomal structure to permit transcription and other DNA-dependent processes to proceed expiditiously.