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Gene Structure of the Murine N-Methyl D-Aspartate Receptor Subunit NR2C

MPG-Autoren
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Suchanek,  Bettina
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Seeburg,  Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Sprengel,  Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;
Rolf Sprengel Group, Max Planck Institute for Medical Research, Max Planck Society;
Olfaction Web, Max Planck Institute for Medical Research, Max Planck Society;

Externe Ressourcen

http://www.jbc.org/content/270/1/41.full.pdf
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https://doi.org/10.1074/jbc.270.1.41
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Zitation

Suchanek, B., Seeburg, P. H., & Sprengel, R. (1994). Gene Structure of the Murine N-Methyl D-Aspartate Receptor Subunit NR2C. The Journal of Biological Chemistry, 270, 41-44. doi:10.1074/jbc.270.1.41.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0019-A97E-A
Zusammenfassung
The murine N-methyl D-aspartate receptor subunit NR2C (epsilon-3) is encoded by a unique gene composed of 12 translated and three 5'-untranslated exons that spread over approximately 20 kilobases of genomic sequence. The GC-rich promoter that lacks TATA- and CAAT-positioning elements has two transcriptional start sites separated by 18 base pairs. One of these sites is located in a conserved initiator motif and, together with the first four exons, specifies the 5'-untranslated sequence of 772 nucleotides. In this sequence, two alternative splice variants were detected that show identical expression patterns in adult mouse brain. Comparison of intron positions in genes encoding different members of the glutamate receptor family confirms a close evolutionary relationship of the NR2C and NMDAR1 subunit genes.