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Journal Article

Cloning and characterization of the rat 5-HT5B receptor


Seeburg,  Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Wisden, W., Parker, E. M., Mahle, C. D., Grisel, D. A., Nowak, H. P., Yocca, F. D., et al. (1993). Cloning and characterization of the rat 5-HT5B receptor. FEBS Letters, 333(1-2), 25-31. doi:10.1016/0014-5793(93)80368-5.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-A9FE-C
A gene encoding a novel G protein-coupled 5-hydroxytryptamine (5-HT) receptor, termed 5-HT5B, was cloned. The ligand binding profile of this receptor is distinct from that of other cloned 5-HT receptors. The 5-HT5B receptor couples to a G protein in COS1 cell membranes; however, activation of the 5-HT5B receptor does not appear to alter either cAMP accumulation or phosphoinositide turnover in a variety of fibroblast cell lines. In the rat brain, 5-HT5B gene expression occurs predominantly in the medial habenulae and hippocampal CA1 cells of the adult. Little expression is seen during embryonic development.