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Argiotoxin detects molecular differences in AMPA receptor channels

MPS-Authors
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Herlitze,  Stefan
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Raditsch,  Martin
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Ruppersberg,  J. Peter
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Jahn,  Werner
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Muscle Research, Max Planck Institute for Medical Research, Max Planck Society;

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Monyer,  Hannah
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Schöpfer,  Ralf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Witzemann,  Veit
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;
Working Group Witzemann / Koenen, Max Planck Institute for Medical Research, Max Planck Society;
Molecular anatomy of the neuromuscular junction, Max Planck Institute for Medical Research, Max Planck Society;
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Herlitze, S., Raditsch, M., Ruppersberg, J. P., Jahn, W., Monyer, H., Schöpfer, R., et al. (1993). Argiotoxin detects molecular differences in AMPA receptor channels. Neuron, 10(6), 1131-1140. doi:10.1016/0896-6273(93)90061-U.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0019-AA46-2
Abstract
Argiotoxin, a component of the spider venom from Argiope lobata, blocks AMPA receptor channels expressed in homomeric and heteromeric configuration in Xenopus oocytes. Argiotoxin acts as an open channel blocker in a voltage-dependent manner and discriminates between the functionally diverse AMPA receptors. Importantly, a transmembrane region 2 determinant for divalent cation permeability also determines argiotoxin sensitivity. Subunit-specific differences in the time courses of block and recovery demonstrate that heteromeric AMPA receptors can assemble in variable ratios. Thus, argiotoxin can be used as a tool in analyzing the subunit composition of AMPA receptors in native membranes.