Solution conformation of the tetrasaccharide glycoside 
Xylβ1-(Manα1-3)2Manβ1-4Glcβ1R from the mollu-series glycosphingolipids

Dabrowski, Ursula; Dabrowski, Janusz; Grosskurth, Horst; Von der Lieth, Claus Wilhelm; Ogawa, Tomoya

doi:10.1006/bbrc.1993.1524

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Solution conformation of the tetrasaccharide glycoside Xylβ1-(Manα1-3)2Manβ1-4Glcβ1R from the mollu-series glycosphingolipids

MPS-Authors

/persons/resource/persons123154

Dabrowski, Ursula
Department of Organic Chemistry, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons92575

Dabrowski, Janusz
Department of Organic Chemistry, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons124278

Grosskurth, Horst
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

External Resource

https://doi.org/10.1006/bbrc.1993.1524
(Any fulltext)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Dabrowski, U., Dabrowski, J., Grosskurth, H., Von der Lieth, C. W., & Ogawa, T. (1993). Solution conformation of the tetrasaccharide glycoside Xylβ1-(Manα1-3)2Manβ1-4Glcβ1R from the mollu-series glycosphingolipids. Biochemical and Biophysical Research Communications, 192(3), 1057-1065. doi:10.1006/bbrc.1993.1524.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-AA5C-1

Abstract

The conformation of Xylβ1-(Manα1-3)2Manβ1-4Glcβ1-OCH2CH(N3)CH(OH) CHCHC13H27 tetrasaccharide glycoside in Me2SO-d6 was investigated with use of a distance mapping procedure based on rotating-frame NOE and hydrogen bond constraints, and Molecular Mechanics calculations. The Manα1-3Manβ linkage was found to be well defined in a single conformation, whereas some flexibility could he assumed for the remaining two glycosidic linkages. Similar conclusions, though based on a smaller number of constraints, were drawn for the title compound anchored in mixed D2O/dodecylphosphocholine-d38 micelles.