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Solution conformation of the tetrasaccharide glycoside Xylβ1-(Manα1-3)2Manβ1-4Glcβ1R from the mollu-series glycosphingolipids

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Dabrowski,  Ursula
Department of Organic Chemistry, Max Planck Institute for Medical Research, Max Planck Society;

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Dabrowski,  Janusz
Department of Organic Chemistry, Max Planck Institute for Medical Research, Max Planck Society;

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Grosskurth,  Horst
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Dabrowski, U., Dabrowski, J., Grosskurth, H., Von der Lieth, C. W., & Ogawa, T. (1993). Solution conformation of the tetrasaccharide glycoside Xylβ1-(Manα1-3)2Manβ1-4Glcβ1R from the mollu-series glycosphingolipids. Biochemical and Biophysical Research Communications, 192(3), 1057-1065. doi:10.1006/bbrc.1993.1524.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0019-AA5C-1
Abstract
The conformation of Xylβ1-(Manα1-3)2Manβ1-4Glcβ1-OCH2CH(N3)CH(OH) CHCHC13H27 tetrasaccharide glycoside in Me2SO-d6 was investigated with use of a distance mapping procedure based on rotating-frame NOE and hydrogen bond constraints, and Molecular Mechanics calculations. The Manα1-3Manβ linkage was found to be well defined in a single conformation, whereas some flexibility could he assumed for the remaining two glycosidic linkages. Similar conclusions, though based on a smaller number of constraints, were drawn for the title compound anchored in mixed D2O/dodecylphosphocholine-d38 micelles.