Mammalian ionotropic glutamate receptors

Wisden, William; Seeburg, Peter H.

doi:10.1016/0959-4388(93)90120-N

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Mammalian ionotropic glutamate receptors

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Seeburg, Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Wisden, W., & Seeburg, P. H. (1993). Mammalian ionotropic glutamate receptors. Current Opinion in Neurobiology, 3(3), 291-298. doi:10.1016/0959-4388(93)90120-N.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-AAD6-F

Abstract

Exciting new milestones in glutamate receptor (GluR) channel research include the following: the cloning of N-methyl-D-aspartate (NMDA) receptors; delineation of molecular determinants for ion flow through glutamate-gated channels; the discovery that Ca2+ permeability of non-NMDA receptor channels is determined by RNA editing; the construction of antibodies and their use in immunocytochemical localizations of alpha-amino-3-hydroxy-5-methyl isoxazole-4-propionic acid (AMPA) receptor subunits in the rat brain; and the return to prominence of the high-affinity kainate site with the publication of cDNA sequences for subunits (GluR-5, -6, -7; KA-1, -2) constituting subtypes of this site. Major unresolved issues comprise the transmembrane topology and subunit stoichiometries of native receptor channels.