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Journal Article

Glutamate-gated ion channels in the brain. Genetic mechanism for generating molecular and functional diversity

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Monyer,  Hannah
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Burnashev,  Nail
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Sprengel,  Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;
Rolf Sprengel Group, Max Planck Institute for Medical Research, Max Planck Society;
Olfaction Web, Max Planck Institute for Medical Research, Max Planck Society;

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Sakmann,  Bert
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Sommer, B., Monyer, H., Wisden, W., Verdoorn, T. A., Burnashev, N., Sprengel, R., et al. (1992). Glutamate-gated ion channels in the brain. Genetic mechanism for generating molecular and functional diversity. Arzneimittel−Forschung, 42(2A), 209-210. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/1375026.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-ABAA-B
Abstract
L-glutamate is the major excitatory neurotransmitter in the vertebrate central nervous system. Most cells are responsive to glutamate which activates cation channels with different pharmacological, kinetic, and ion permeability properties. These channels play important roles in neurotransmission, memory acquisition as well as acute and chronic disorders of the brain. The present report summarizes recent knowledge on AMPA (a-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid) receptors which mediate fast synaptic neurotransmission.