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Journal Article

Proton NMR studies of the GDP.Mg2+ complex of the Ha-ras oncogene product p21

MPS-Authors
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Schlichting,  Ilme
Photoreceptors, Max Planck Institute for Medical Research, Max Planck Society;
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Wittinghofer,  Alfred
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons95056

Rösch,  Paul
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

External Resource

https://www.sciencedirect.com/science/article/pii/0006291X88905402/pdf?md5=7c655777978aeaa93259cfcdafd69836&pid=1-s2.0-0006291X88905402-main.pdf
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https://doi.org/10.1016/0006-291X(88)90540-2
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Citation

Schlichting, I., Wittinghofer, A., & Rösch, P. (1988). Proton NMR studies of the GDP.Mg2+ complex of the Ha-ras oncogene product p21. Biochemical and Biophysical Research Communications, 150(1), 444-448. doi:10.1016/0006-291X(88)90540-2.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-AE1C-4
Abstract
Two-dimensional proton NMR studies were performed on the c-Ha-ras encoded proto-oncogene product p21C. COSY and NOESY spectra of the p21C.GDP.Mg2+ complex show that the ribose H1 proton of the bound GDP is in close proximity to the aromatic side chain of a phenylalanyl residue. From sequence homology with the bacterial elongation factor Tu (EF-Tu) and the known X-ray structure of the EF-Tu.GDP.Mg2+ complex it may be inferred that the Phe residue in question is either Phe78 or Phe82 in the p21 sequence.