Interpretation of the low angle X-ray diffraction from insect flight muscle in 
rigor

Holmes, Kenneth C.; Tregear, Richard T.; Barrington Leigh, John

doi:10.1098/rspb.1980.0012

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Interpretation of the low angle X-ray diffraction from insect flight muscle in rigor

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Holmes, Kenneth C.
Protein Cristallography XDS, Max Planck Institute for Medical Research, Max Planck Society;
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Muscle Research, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Holmes, K. C., Tregear, R. T., & Barrington Leigh, J. (1980). Interpretation of the low angle X-ray diffraction from insect flight muscle in rigor. Proceedings of the Royal Society B: Biological Sciences, 207(1166), 13-33. doi:10.1098/rspb.1980.0012.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-B08C-B

Abstract

The structure of insect flight muscle is formally described in terms of actin-based cross-bridges upon which successive symmetry operations are performed, in combination with a modulation function. The Fourier transform of the structure is generated by means of these steps. The model transform is fitted to the observed diffraction pattern from insect flight muscle in rigor and the position of the rigor cross-bridges deduced; they are found to lie across the long helix of actin monomers and to project away from the thin filament. The cross-bridges interact with approximately one-third of the actin monomers, and show a strong preference for a particular orientation between the thick and thin filaments.