Low resolution structure of adenylate kinase

Schulz, Georg E.; Biedermann, K.; Kabsch, Wolfgang; Schirmer, R. Heiner

doi:10.1016/0022-2836(73)90214-3

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Low resolution structure of adenylate kinase

MPS-Authors

/persons/resource/persons123190

Schulz, Georg E.
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons93650

Kabsch, Wolfgang
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society;

External Resource

http://www.sciencedirect.com/science/article/pii/0022283673902143/pdf?md5=552075b43a7919a7f95d20352de21ade&pid=1-s2.0-0022283673902143-main.pdf
(全文テキスト（全般）)

https://doi.org/10.1016/0022-2836(73)90214-3
(全文テキスト（全般）)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Schulz, G. E., Biedermann, K., Kabsch, W., & Schirmer, R. H. (1973). Low resolution structure of adenylate kinase. Journal of Molecular Biology, 80(4), 857-864. doi:10.1016/0022-2836(73)90214-3.

引用: https://hdl.handle.net/11858/00-001M-0000-0019-B17F-1

要旨

A low resolution model of adenylate kinase has been derived from a 6 Å electron density map. The molecular shape can be described approximately as an oblate ellipsoid with dimensions 40 Å × 40 Å × 30 Å. The molecule is composed of two globular units separated by a 10 Å deep cleft. In contrast to the bigger unit, the smaller globule appears to contain a high amount of α-helical structure. The location of the active centre is discussed. The crystals used for X-ray diffraction analysis belong to one of the enantiomorphic trigonal space groups P3121 or P3221, with one molecule in the asymmetric unit. The phase determination was based on four isomorphous heavy atom derivatives. Frequent transitions between different crystal forms complicate the analysis.