Plasticity of dendritic spines: subcompartmentalization of signaling

Colgan, L. A.; Yasuda, R.

doi:10.1146/annurev-physiol-021113-170400

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Plasticity of dendritic spines: subcompartmentalization of signaling

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Colgan, L. A.
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Yasuda, R.
Max Planck Florida Institute for Neuroscience, Max Planck Society;

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Citation

Colgan, L. A., & Yasuda, R. (2014). Plasticity of dendritic spines: subcompartmentalization of signaling. Annual Review of Physiology, 76(2014), 365-385. doi:10.1146/annurev-physiol-021113-170400.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-00BA-6

Abstract

The ability to induce and study neuronal plasticity in single dendritic spines has greatly advanced our understanding of the signaling mechanisms that mediate long-term potentiation. It is now clear that in addition to compartmentalization by the individual spine, subcompartmentalization of biochemical signals occurs at specialized microdomains within the spine. The spatiotemporal coordination of these complex cascades allows for the concomitant remodeling of the postsynaptic density and actin spinoskeleton and for the regulation of membrane traffic to express functional and structural plasticity. Here, we highlight recent findings in the signaling cascades at spine microdomains as well as the challenges and approaches to studying plasticity at the spine level.