Plasticity of dendritic spines: subcompartmentalization of signaling

Colgan, L. A.; Yasuda, R.

doi:10.1146/annurev-physiol-021113-170400

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学術論文

Plasticity of dendritic spines: subcompartmentalization of signaling

MPS-Authors

Colgan, L. A.
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Yasuda, R.
Max Planck Florida Institute for Neuroscience, Max Planck Society;

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引用

Colgan, L. A., & Yasuda, R. (2014). Plasticity of dendritic spines: subcompartmentalization of signaling. Annual Review of Physiology, 76(2014), 365-385. doi:10.1146/annurev-physiol-021113-170400.

引用: https://hdl.handle.net/11858/00-001M-0000-0019-00BA-6

要旨

The ability to induce and study neuronal plasticity in single dendritic spines has greatly advanced our understanding of the signaling mechanisms that mediate long-term potentiation. It is now clear that in addition to compartmentalization by the individual spine, subcompartmentalization of biochemical signals occurs at specialized microdomains within the spine. The spatiotemporal coordination of these complex cascades allows for the concomitant remodeling of the postsynaptic density and actin spinoskeleton and for the regulation of membrane traffic to express functional and structural plasticity. Here, we highlight recent findings in the signaling cascades at spine microdomains as well as the challenges and approaches to studying plasticity at the spine level.