Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Molecular and Functional Asymmetry at a Vertebrate Electrical Synapse


Kamasawa,  Naomi
Max Planck Florida Institute for Neuroscience, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Rash, J., Curti, S., Vanderpool, K., Kamasawa, N., Nannapaneni, S., Palacios-Prado, N., et al. (2013). Molecular and Functional Asymmetry at a Vertebrate Electrical Synapse. Neuron, 79(5), 957-969. doi:10.1016/j.neuron.2013.06.037.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-0E23-8
Electrical synapses are abundant in the vertebrate brain, but their functional and molecular complexities are still poorly understood. We report here that electrical synapses between auditory afferents and goldfish Mauthner cells are constructed by apposition of hemichannels formed by two homologs of mammalian connexin 36 (Cx36) and that, while Cx35 is restricted to presynaptic hemiplaques, Cx34.7 is restricted to postsynaptic hemiplaques, forming heterotypic junctions. This molecular asymmetry is associated with rectification of electrical transmission that may act to promote cooperativity between auditory afferents. Our data suggest that, in similarity to pre- and postsynaptic sites at chemical synapses, one side in electrical synapses should not necessarily be considered the mirror image of the other. While asymmetry based on the presence of two Cx36 homologs is restricted to teleost fish, it might also be based on differences in posttranslational modifications of individual connexins or in the complement of gap junction-associated proteins.