Undressing of phosphine gold(I) complexes as irreversible inhibitors of human 
disulfide reductases

Urig, Sabine; Fritz-Wolf, Karin; Réau, Régis; Herold-Mende, Christel; Tóth, Katalin; Davioud-Charvet, Elisabeth; Becker, Katja

doi:10.1002/anie.200502756

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Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases

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Fritz-Wolf, Karin
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Urig, S., Fritz-Wolf, K., Réau, R., Herold-Mende, C., Tóth, K., Davioud-Charvet, E., et al. (2006). Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases. Angew. Chem. Internat. Ed., 45(12), 1881-1886. doi:10.1002/anie.200502756.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-8E4B-7

Abstract

Redox-based chemotherapy: The irreversible inhibition of human glutathione reductase results in a unique S-AuI-S coordination, which was determined crystallographically. The chemotherapeutic potential of phosphine–metal complexes was probed by kinetic analysis of the fast and effective inhibition of redox enzymes as well as by DNA-interaction studies and cell-proliferation tests.