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Structural brain changes in early-onset and late-onset depression: An update of volumetric MRI findings

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Sacher,  Julia
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

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Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

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Citation

Tittmann, M., Günther, T., Sacher, J., Himmerich, H., Villringer, A., Hegerl, U., et al. (2014). Structural brain changes in early-onset and late-onset depression: An update of volumetric MRI findings. International Journal of Imaging Systems and Technology, 24(2), 149-160. doi:10.1002/ima.22089.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0019-C17F-F
Abstract
Early-onset (EOD) and late-onset depression (LOD) are associated with different neuropsychological syndromes and structural brain changes. In this article, neuroimaging studies examining structural brain changes in elderly depressed patients are reviewed. The presented findings support current assumptions that depression in the elderly generally is associated with volume reductions in brain structures, notably in the hippocampus and the orbitofrontal cortex (OFC). Concerning structural cerebral differences between EOD and LOD, the review yielded conflicting results—only for OFC, but not for amygdala or hippocampus, pronounced effects in LOD than in EOD can be assumed.