Highly enantioselective synthesis of 1,2-amino alcohol derivatives via 
proline-catalyzed Mannich reaction

Pojarliev, P.; Biller, WT; Martin, Heinz; List, Benjamin

doi:10.1055/s-2003-41491

Item

ITEM ACTIONSEXPORT

Add to Basket

Please note that a newer version of this item is available:
https://pure.mpg.de/pubman/item/item_2036330_4

DetailsSummary

Released

Journal Article

Highly enantioselective synthesis of 1,2-amino alcohol derivatives via proline-catalyzed Mannich reaction

MPS-Authors

/persons/resource/persons58802

Martin, Heinz
Research Group Martin, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

/persons/resource/persons58764

List, Benjamin
Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Pojarliev, P., Biller, W., Martin, H., & List, B. (2003). Highly enantioselective synthesis of 1,2-amino alcohol derivatives via proline-catalyzed Mannich reaction. Synlett, 12, 1903-1905. doi:10.1055/s-2003-41491.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-D5FC-9

Abstract

Here we report a new catalytic asymmetric synthesis of oxazolidin-2-ones 4 and Cbz-protected 1,2-amino alcohols 5. Our sequence is based on the chemistry of previously unknown 5-acyloxy-oxazolidin-2-ones, which are obtained via proline-catalyzed direct asymmetric three-component Mannich reaction and Baeyer-Villiger oxidation