English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

The upper respiratory tract as a microbial source for pulmonary infections in cystic fibrosis: parallels from island biogeography

MPS-Authors
/persons/resource/persons56872

Rainey,  Paul B.
External Scientific Member Group Experimental and Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Whiteson, K. L., Bailey, B., Bergkessel, M., Conrad, D., Delhaes, L., Felts, B., et al. (2014). The upper respiratory tract as a microbial source for pulmonary infections in cystic fibrosis: parallels from island biogeography. American Journal of Respiratory and Critical Care Medicine, 189(11), 1309-1315. doi:0.1164/rccm.201312-2129PP.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0019-D838-B
Abstract
A continuously mixed series of microbial communities inhabits various points of the respiratory tract, with community composition determined by distance from colonization sources, colonization rates, and extinction rates. Ecology and evolution theory developed in the context of biogeography is relevant to clinical microbiology and could reframe the interpretation of recent studies comparing communities from lung explant samples, sputum samples, and oropharyngeal swabs. We propose an island biogeography model of the microbial communities inhabiting different niches in human airways. Island biogeography as applied to communities separated by time and space is a useful parallel for exploring microbial colonization of healthy and diseased lungs, with the potential to inform ourunderstanding ofmicrobial community dynamics and the relevance of microbes detected in different sample types. In this perspective, we focus on the intermixed microbial communities inhabiting different regions of the airways of patients with cystic fibrosis.