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DNA damage Mechanisms and principles of homology search during recombination

MPG-Autoren
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Renkawitz,  Jörg
Jentsch, Stefan / Molecular Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Lademann,  Claudio A.
Jentsch, Stefan / Molecular Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Jentsch,  Stefan
Jentsch, Stefan / Molecular Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Zitation

Renkawitz, J., Lademann, C. A., & Jentsch, S. (2014). DNA damage Mechanisms and principles of homology search during recombination. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 15(6), 369-383. doi:10.1038/nrm3805.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0019-FB53-2
Zusammenfassung
Homologous recombination is crucial for genome stability and for genetic exchange. Although our knowledge of the principle steps in recombination and its machinery is well advanced, homology search, the critical step of exploring the genome for homologous sequences to enable recombination, has remained mostly enigmatic. However, recent methodological advances have provided considerable new insights into this fundamental step in recombination that can be integrated into a mechanistic model. These advances emphasize the importance of genomic proximity and nuclear organization for homology search and the critical role of homology search mediators in this process. They also aid our understanding of how homology search might lead to unwanted and potentially disease-promoting recombination events.