Feasibility of quantitative diffusion imaging of the heart in post-mortem MR

Crooijmans, HJA; Ruder, TD; Zech, W-D; Somaini, S; Scheffler, Klaus; Thali, MJ; Bieri, O

doi:10.1016/j.jofri.2013.05.009

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Feasibility of quantitative diffusion imaging of the heart in post-mortem MR

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Scheffler, Klaus
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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http://www.sciencedirect.com/science/article/pii/S2212478013000701
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Crooijmans, H., Ruder, T., Zech, W.-D., Somaini, S., Scheffler, K., Thali, M., et al. (2013). Feasibility of quantitative diffusion imaging of the heart in post-mortem MR. Journal of Forensic Radiology and Imaging, 1(3), 124-128. doi:10.1016/j.jofri.2013.05.009.

Cite as: https://hdl.handle.net/11858/00-001M-0000-001A-13FE-A

Abstract

Objective The aim of this work was to investigate the feasibility of quantitative diffusion imaging of the heart in a post-mortem setting and compare these results to standard T2-weighted imaging as well as to traditional autopsy and histological analysis. Materials and methods Two human cadavers underwent post-mortem magnetic resonance (PMMR) imaging of the heart, autopsy and histological analysis of the myocardium. Diffusion weighted double-echo steady-state data with direction sensitivity in three orthogonal directions have been acquired from which the mean-diffusivity has been estimated. In addition, T2-weighted data have been acquired. PMMR images were compared to autopsy and histology. Results Direction dependent diffusivity-maps revealed a strong dependency on the orientation of the myocardial fibers; the resulting mean-diffusivity-maps are independent of the fiber direction. Findings in the mean-diffusivity-maps revealed good correspondence to findings in T2-weighted images as well as to the autopsy and histology findings. Long axis reconstructions of the mean-diffusivity-maps gave further insight into the extent of an acute infarction of one case. Conclusions This study shows that quantitative diffusion imaging of the heart is applicable in a post-mortem setting to identify scar-tissue as well as acute infarction in the myocardium. Three-dimensional isotropic diffusivity-mapping additionally allows for the reconstruction of slices in any orientation for optimal visualization of the results.