Development of a new photochromic ion channel blocker via azologization of 
fomocaine

Schoenberger, Matthias; Damijonaitis, Arunas; Zhang, Zinan; Nagel, Daniel; Trauner, Dirk

doi:10.1021/cn500070w

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Development of a new photochromic ion channel blocker via azologization of fomocaine

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Nagel, Daniel
Department: Molecules-Signaling-Development / Klein, MPI of Neurobiology, Max Planck Society;

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Citation

Schoenberger, M., Damijonaitis, A., Zhang, Z., Nagel, D., & Trauner, D. (2014). Development of a new photochromic ion channel blocker via azologization of fomocaine. ACS Chemical Neuroscience, 5(7), 514-518. doi:10.1021/cn500070w.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0023-C261-1

Abstract

Photochromic blockers of voltage gated ion channels are powerful tools for the control of neuronal systems with high spatial and temporal precision. We now introduce fotocaine, a new type of photochromic channel blocker based on the long-lasting anesthetic fomocaine. Fotocaine is readily taken up by neurons in brain slices and enables the optical control of action potential firing by switching between 350 and 450 nm light. It also provides an instructive example for "azologization", that is, the systematic conversion of an established drug into a photoswitchable one.