On the Origin of π-Facial Diastereoselectivity in nucleophilic additions to 
chiral carbonyl compounds 4. Calculated transition state structures for the 
addition of nucleophiles to 2-methoxypropanal and 2-N,N-dimethyl-aminopropanal.

Frenking, G.; Köhler, K.F.; Reetz, Manfred T.

doi:10.1016/S0040-4020(01)89912-9

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

On the Origin of π-Facial Diastereoselectivity in nucleophilic additions to chiral carbonyl compounds 4. Calculated transition state structures for the addition of nucleophiles to 2-methoxypropanal and 2-N,N-dimethyl-aminopropanal.

MPS-Authors

Frenking, G.
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Fachbereich Chemie, Philipps-Universität Marburg;

Köhler, K.F.
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Fachbereich Chemie, Philipps-Universität Marburg;

/persons/resource/persons58919

Reetz, Manfred T.
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Fachbereich Chemie, Philipps-Universität Marburg;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Frenking, G., Köhler, K., & Reetz, M. T. (1993). On the Origin of π-Facial Diastereoselectivity in nucleophilic additions to chiral carbonyl compounds 4. Calculated transition state structures for the addition of nucleophiles to 2-methoxypropanal and 2-N,N-dimethyl-aminopropanal. Tetrahedron, 49(19), 3983-3984. doi:10.1016/S0040-4020(01)89912-9.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0023-CAF9-F

Abstract

The transition state structures of the nucleophilic addition of LiH to 2-methoxypropanal and 2-N,N-dimethylaminopropanal have been calculated using ab initio methods at the MP2/6-31G*//3-21G level of theory. The analysis of the theoretical data shows that Coulombic, electronic and steric interactions as well as conformational energies may be dominant for determining the energetically lowest lying transition states.