No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic 
brain structure

Cousijn, Helena; Eissing, Marc; Fernández , Guillén; Fisher, Simon E.; Franke, Barbara; Zwers, Marcel; Harrison, Paul J.; Arias-Vasquez, Alejandro

doi:10.1016/j.schres.2014.08.007

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No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure

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Fisher, Simon E.
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society;
Donders Institute for Brain, Cognition and Behaviour, External Organizations;

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http://www.sciencedirect.com/science/article/pii/S0920996414004186#appd001
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Citation

Cousijn, H., Eissing, M., Fernández, G., Fisher, S. E., Franke, B., Zwers, M., et al. (2014). No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure. Schizophrenia Research, 159, 329-332. doi:10.1016/j.schres.2014.08.007.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0023-CE00-0

Abstract

Single nucleotide polymorphisms (SNPs) within the MIR137, TCF4, and ZNF804A genes show genome-wide association to schizophrenia. However, the biological basis for the associations is unknown. Here, we tested the effects of these genes on brain structure in 1300 healthy adults. Using volumetry and voxel-based morphometry, neither gene-wide effects—including the combined effect of the genes—nor single SNP effects—including specific psychosis risk SNPs—were found on total brain volume, grey matter, white matter, or hippocampal volume. These results suggest that the associations between these risk genes and schizophrenia are unlikely to be mediated via effects on macroscopic brain structure.