Serotonergic modulation of intrinsic functional connectivity

Schäfer, Alexander; Burmann, Inga; Regenthal, Ralf; Arélin, Katrin; Barth, Claudia; Pampel, André; Villringer, Arno; Margulies, Daniel S.; Sacher, Julia

doi:10.1016/j.cub.2014.08.024

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Serotonergic modulation of intrinsic functional connectivity

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Schäfer, Alexander
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department of Electrical and Computer Engineering, Clinical Imaging Research Centre & Singapore Institute for Neurotechnology, National University of Singapore, Singapore;

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Burmann, Inga
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Arélin, Katrin
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany;

Barth, Claudia
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Pampel, André
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Villringer, Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany;
Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany;
Berlin School of Mind and Brain, Humboldt University Berlin, Germany;

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Margulies, Daniel S.
Berlin School of Mind and Brain, Humboldt University Berlin, Germany;
Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19956

Sacher, Julia
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Berlin School of Mind and Brain, Humboldt University Berlin, Germany;

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https://doi.org/10.1016/j.cub.2014.08.024
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Citation

Schäfer, A., Burmann, I., Regenthal, R., Arélin, K., Barth, C., Pampel, A., et al. (2014). Serotonergic modulation of intrinsic functional connectivity. Current Biology, 24(19), 2314-2318. doi:10.1016/j.cub.2014.08.024.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0023-EDB3-2

Abstract

Serotonin functions as an essential neuromodulator that serves a multitude of roles, most prominently balancing mood [1]. Serotonergic challenge has been observed to reduce intrinsic functional connectivity in brain regions implicated in mood regulation [2-4]. However, the full scope of serotonergic action on functional connectivity in the human brain has not been explored. Here, we show evidence that a single dose of a serotonin reuptake inhibitor dramatically alters functional connectivity throughout the whole brain in healthy subjects (n = 22). Our network-centrality analysis reveals a widespread decrease in connectivity in most cortical and subcortical areas. In the cerebellum and thalamus, however, we find localized increases. These rapid and brain-encompassing connectivity changes linked to acute serotonin transporter blockade suggest a key role for the serotonin transporter in the modulation of the functional macroscale connectome.