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Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice

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Seeburg,  Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Sprengel,  Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Taylor, A. M., Niewoehner, B., Seeburg, P. H., Sprengel, R., Rawlins, J. N. P., Bannerman, D. M., et al. (2011). Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice. Behavioural Brain Research, 224(1), 8-14. doi:10.1016/j.bbr.2011.05.016.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-1FAB-7
Abstract
GluA1 AMPA receptor subunit knockout mice display a selective impairment on short−term recognition memory tasks. In this study we tested whether GluA1 is important for short−term memory that is necessary for bridging the discontiguity between cues in trace conditioning. GluA1 knockout mice were not impaired at using short−term memory traces of T−maze floor inserts, made of different materials, to bridge the temporal gap between conditioned stimuli and reinforcement during appetitive discrimination tasks. Thus, different aspects of short−term memory are differentially sensitive to GluA1 deletion. This dissociation may reflect processing of qualitatively different short−term memory traces. Memory that results in performance of short−term recognition (e.g. for objects or places) may be different from the memory required for associative learning in trace conditioning