Bioconjugated Iron Oxide Nanocubes: Synthesis, Functionalization, and 
Vectorization

Wortmann, Laura; Ilyas, Shaista; Niznansky, Daniel; Valldor, Martin; Arroub, Karim; Berger, Nadja; Rahme, Kamil; Holmes, Justin; Mathur, Sanjay

doi:10.1021/am503068r

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Bioconjugated Iron Oxide Nanocubes: Synthesis, Functionalization, and Vectorization

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Valldor, Martin
Martin Valldor, Physics of Correlated Matter, Max Planck Institute for Chemical Physics of Solids, Max Planck Society;

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Citation

Wortmann, L., Ilyas, S., Niznansky, D., Valldor, M., Arroub, K., Berger, N., et al. (2014). Bioconjugated Iron Oxide Nanocubes: Synthesis, Functionalization, and Vectorization. ACS Applied Materials & Interfaces, 6(19), 16631-16642. doi:10.1021/am503068r.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-3455-4

Abstract

A facile bottom-up approach for the synthesis of inorganic/organic bioconjugated nanoprobes based on iron oxide nanocubes as the core with a nanometric silica shell is demonstrated. Surface coating and functionalization protocols developed in this work offered good control over the shell thickness (840 nm) and enabled biovectorization of SiO2@Fe3O4 coreshell structures by covalent attachment of folic acid (FA) as a targeting unit for cellular uptake. The successful immobilization of folic acid was investigated both quantitatively (TGA, EA, XPS) and qualitatively (AT-IR, UVvis, zeta-potential). Additionally, the magnetic behavior of the nanocomposites was monitored after each functionalization step. Cell viability studies confirmed low cytotoxicity of FA@SiO2@Fe3O4 conjugates, which makes them promising nanoprobes for targeted internalization by cells and their imaging.