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Journal Article

Relation between rise times and amplitudes of GABAergic postsynaptic currents


Borst,  J. Gerard G.
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Bier, M., Kits, K. S., & Borst, J. G. G. (1996). Relation between rise times and amplitudes of GABAergic postsynaptic currents. Journal of Neurophysiology, 75(3), 1008-1012. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/8867113.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-40B0-6
1. We recorded rise times and amplitudes of spontaneous GABAergic inhibitory postsynaptic currents (IPSCs) in melanotropes of Xenopus laevis. Average rise times did not vary with amplitude, but the rise times of larger IPSCs were less variable. A simple linear one−step Markov model for channel opening following the binding of a transmitter molecule can quantitatively account for the average rise time and its coefficient of variation as a function of amplitude. Our results indicate that the observed variations in the rise times are not due to variations in transmitter concentrations, but result from stochastic variations in the opening of the receptor channels