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Journal Article

Calcium permeability of glutamate-gated channels in the central nervous system


Burnashev,  Nail
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Burnashev, N. (1996). Calcium permeability of glutamate-gated channels in the central nervous system. Current Opinion in Neurobiology, 6(3), 311-317. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd%3DRetrieve%26db%3DPubMed%26list_uids%3D8794087%26dopt%3DAbstract.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-40C2-D
Molecular cloning of ionotropic glutamate receptors and the development of new measurement techniques have significantly advanced our understanding of the molecular mechanisms controlling ligand−mediated entry of Ca2+ into neurons of the mammalian CNS. Recent studies have demonstrated that various types of glutamate receptors expressed in different nerve cells are permeable to Ca2+ to variable extents, depending on the structural peculiarities of the subunits and their composition in a particular cell. This diversity provides a regulable pathway for Ca2+ entry during synaptic transmission. The fractional contribution of this Ca2+ to the total synaptic current might be a substantial means of elevating the intracellular Ca2+ concentration over a wide temporal range