Calcium permeability of glutamate-gated channels in the central nervous system

Burnashev, Nail

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Calcium permeability of glutamate-gated channels in the central nervous system

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Burnashev, Nail
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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http://pdn.sciencedirect.com/science?_ob=MiamiImageURL&_cid=272014&_user=41901&_pii=S0959438896801139&_check=y&_origin=article&_zone=toolbar&_coverDate=30-Jun-1996&view=c&originContentFamily=serial&wchp=dGLbVlt-zSkzk&md5=7006675d30573d7e1ee0e05bc23026a3&pid=1-s2.0-S0959438896801139-main.pdf
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Citation

Burnashev, N. (1996). Calcium permeability of glutamate-gated channels in the central nervous system. Current Opinion in Neurobiology, 6(3), 311-317. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd%3DRetrieve%26db%3DPubMed%26list_uids%3D8794087%26dopt%3DAbstract.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-40C2-D

Abstract

Molecular cloning of ionotropic glutamate receptors and the development of new measurement techniques have significantly advanced our understanding of the molecular mechanisms controlling ligand−mediated entry of Ca²⁺ into neurons of the mammalian CNS. Recent studies have demonstrated that various types of glutamate receptors expressed in different nerve cells are permeable to Ca²⁺ to variable extents, depending on the structural peculiarities of the subunits and their composition in a particular cell. This diversity provides a regulable pathway for Ca²⁺ entry during synaptic transmission. The fractional contribution of this Ca²⁺ to the total synaptic current might be a substantial means of elevating the intracellular Ca²⁺ concentration over a wide temporal range