Exercise Boosts Hippocampal Volume by Preventing Early Age-Related Gray Matter 
Loss

Fuss, Johannes; Biedermann, Sarah V.; Falfan-Melgoza, Claudia; Auer, Matthias K.; Zheng, Lei; Steinle, Joerg; Hoerner, Felix; Sartorius, Alexander; Ende, Gabriele; Weber-Fahr, Wolfgang; Gass, Peter

doi:10.1002/hipo.22227

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Exercise Boosts Hippocampal Volume by Preventing Early Age-Related Gray Matter Loss

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Auer, Matthias K.
Dept. Clinical Research, Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Fuss, J., Biedermann, S. V., Falfan-Melgoza, C., Auer, M. K., Zheng, L., Steinle, J., et al. (2014). Exercise Boosts Hippocampal Volume by Preventing Early Age-Related Gray Matter Loss. HIPPOCAMPUS, 24(2), 131-134. doi:10.1002/hipo.22227.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0026-ADFE-C

Abstract

Recently, a larger hippocampus was found in exercising mice and men. Here we studied the morphological underpinnings in wheel running mice by longitudinal magnetic resonance imaging. Voxel-based morphometry revealed that running increases hippocampal volume by inhibiting an early age-related gray matter loss. Disruption of neurogenesis-related neuroplasticity by focalized irradiation is sufficient to block positive effects of exercise on macroscopic brain morphology. (c) 2013 Wiley Periodicals, Inc.