Genetic Interactions with Sex Make a Relatively Small Contribution to the 
Heritability of Complex Traits in Mice

Krohn, Jon; Speed, Doug; Palme, Rupert; Touma, Chadi; Mott, Richard; Flint, Jonathan

doi:10.1371/journal.pone.0096450

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Genetic Interactions with Sex Make a Relatively Small Contribution to the Heritability of Complex Traits in Mice

MPS-Authors

/persons/resource/persons80557

Touma, Chadi
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

journal.pone.0096450.pdf
(全文テキスト（全般）), 867KB

付随資料 (公開)

There is no public supplementary material available

引用

Krohn, J., Speed, D., Palme, R., Touma, C., Mott, R., & Flint, J. (2014). Genetic Interactions with Sex Make a Relatively Small Contribution to the Heritability of Complex Traits in Mice. PLOS ONE, 9(5):. doi:10.1371/journal.pone.0096450.

引用: https://hdl.handle.net/11858/00-001M-0000-0024-CC3B-7

要旨

The extent to which sex-specific genetic effects contribute to phenotypic variation is largely unknown. We applied a novel Bayesian method, sparse partitioning, to detect gene by sex (GxS) and gene by gene (GxG) quantitative loci (QTLs) in 1,900 outbred heterogeneous stock mice. In an analysis of 55 phenotypes, we detected 16 GxS and 6 GxG QTLs. The increase in the amount of phenotypic variance explained by models including GxS was small, ranging from 0.14% to 4.30%. We conclude that GxS rarely make a large overall contribution to the heritability of phenotypes, however there are cases where these will be individually important.