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Behavioral phenotyping of Nestin-Cre mice: Implications for genetic mouse Models of psychiatric disorders

MPG-Autoren
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Giusti,  Sebastian A.
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

Vercelli,  Claudia A.
Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET-Partner Institute of the Max Planck Society;

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Vogl,  Annette M.
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

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Kolarz,  Adam W.
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Pino,  Natalia S.
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

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Deussing,  Jan M.
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Refojo,  Damian
Max Planck Research Group Molecular Neurobiology (Damian Refojo), Max Planck Institute of Psychiatry, Max Planck Society;

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Zitation

Giusti, S. A., Vercelli, C. A., Vogl, A. M., Kolarz, A. W., Pino, N. S., Deussing, J. M., et al. (2014). Behavioral phenotyping of Nestin-Cre mice: Implications for genetic mouse Models of psychiatric disorders. JOURNAL OF PSYCHIATRIC RESEARCH, 55, 87-95. doi:10.1016/j.jpsychires.2014.04.002.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0024-7010-2
Zusammenfassung
Genetic mouse models based on the Cre-loxP system have been extensively used to explore the influence of specific gene deletions on different aspects of behavioral neurobiology. However, the interpretation of the effects attributed to the gene deletion might be obscured by potential side effects secondary to the Cre recombinase transgene insertion or Cre activity, usually neither controlled nor reported. Here, we performed a comprehensive behavioral analysis of endophenotypes of neuropsychiatric disorders in the extensively used Nestin(Cre) mouse line, commonly employed to restrict genetic modifications to the CNS. We observed no alterations in locomotion, general exploratory activity, learning and memory, sociability, startle response and sensorimotor gating. Although the overall response to stimuli triggering anxiety-like behaviors remained unaltered in Nestin(Cre) mice, a strong impairment in the acquisition of both contextual- and cued-conditioned fear was observed. These results underline the importance of adequately controlling the behavioral performance of the employed Cre-lines per-se in pre-clinical neurobehavioral research. (C) 2014 Elsevier Ltd. All rights reserved.