English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Local CRH Signaling Promotes Synaptogenesis and Circuit Integration of Adult-Born Neurons

MPS-Authors
/persons/resource/persons80301

Deussing,  Jan Michael
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Garcia, I., Quast, K. B., Huang, L., Herman, A. M., Selever, J., Deussing, J. M., et al. (2014). Local CRH Signaling Promotes Synaptogenesis and Circuit Integration of Adult-Born Neurons. DEVELOPMENTAL CELL, 30(6), 645-659. doi:10.1016/j.devcel.2014.07.001.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0024-5ED3-9
Abstract
Neural activity either enhances or impairs de novo synaptogenesis and circuit integration of neurons, but how this activity is mechanistically relayed in the adult brain is largely unknown. Neuropeptide-expressing interneurons are widespread throughout the brain and are key candidates for conveying neural activity downstream via neuromodulatory pathways that are distinct from classical neurotransmission. With the goal of identifying signaling mechanisms that underlie neuronal circuit integration in the adult brain, we have virally traced local corticotropin-releasing hormone (CRH)-expressing inhibitory interneurons with extensive presynaptic inputs onto new neurons that are continuously integrated into the adult rodent olfactory bulb. Local CRH signaling onto adult-born neurons promotes and/or stabilizes chemical synapses in the olfactory bulb, revealing a neuromodulatory mechanism for continued circuit plasticity, synapse formation, and integration of new neurons in the adult brain.