English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure.

MPS-Authors
/persons/resource/persons31230

Wachowius,  F.
Research Group of Nucleic Acid Chemistry, MPI for biophysical chemistry, Max Planck Society;

/persons/resource/persons15234

Höbartner,  C.
Research Group of Nucleic Acid Chemistry, MPI for biophysical chemistry, Max Planck Society;

Fulltext (public)

2075834.pdf
(Publisher version), 3MB

Supplementary Material (public)

2075834_Suppl.pdf.part
(Supplementary material), 190KB

Citation

Schmidtgall, B., Spork, A. P., Wachowius, F., Höbartner, C., & Ducho, C. (2014). Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure. Chemical Communications, 50(89), 13742-13745. doi:10.1039/C4CC06371F.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0024-445C-A
Abstract
The nucleosyl amino acid (NAA)-modification of oligonucleotides is introduced, which enables the preparation of oligonucleotides with zwitterionic backbone structures. It is demonstrated that partially zwitterionic NAA-modified DNA oligonucleotides are capable of duplex formation with native polyanionic counterstrands and show retained sensitivity towards base-pairing mismatches.